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characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cellacute lymphoblastic leukemia: targeted immunotherapy for acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 139-149 doi: 10.1007/s11684-021-0835-8

Abstract: The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients withrelapsed/refractory B-cell precursor acute lymphoblastic leukemia.and A-2019 are potent antitumor agents and capable of recruiting CD3 positive T cells, enhancing T-cellfunction, mediating B-cell depletion, and eventually inhibiting tumor growth in Raji xenograft models

Keywords： B-cell acute lymphoblastic leukemia     bispecific antibody     trispecific antibody     CD19     CD20    

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Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 416-420 doi: 10.1007/s11684-012-0224-4

Abstract:

Acute lymphoblastic leukemia includes T-cell acute lymphoblastic leukemia (T-ALL) and B-cell acutelymphoblastic leukemia (B-ALL).This novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia (ETP-ALL).Our findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblasticleukemia with poor prognosis.

Keywords： acute lymphoblastic leukemia     early T precursor     prognosis    

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is one of the most dangerous hematological malignancies,We found that chidamide, an HDAC inhibitor, exerts an antitumor effect on T-ALL cell lines and primary

Keywords： T-cell acute lymphoblastic leukemia     HDAC inhibitor     chidamide     NOTCH1     MYC     ubiquitination    

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Precision medicine in acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 689-700 doi: 10.1007/s11684-020-0759-8

Abstract: The cure rate of childhood acute lymphoblastic leukemia (ALL) has exceeded 90% in some contemporary clinicaland other preclinical methods have identified several high-risk subtypes, such as hypodiplod, early T-cellprecursor, immature T-cell, -rearranged, Ph-positive and -positive ALL, that may respond to BCL-2targetable genetic lesions, current approaches that offer hope include blinatumomab, inotuzumab and CAR-T celltherapy for B-ALL, and daratumumab and nelarabine for T-ALL.

Keywords： acute lymphoblastic leukemia     molecular therapeutics     targeted therapy     tyrosine kinase inhibitors     immunotherapy     CAR T-cell therapy    

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Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 518-526 doi: 10.1007/s11684-022-0958-6

Abstract: Venous thromboembolism (VTE) is a complication in children with acute lymphoblastic leukemia (ALL).

Keywords： acute lymphoblastic leukemia     child     venous thromboembolism     epidemiology     clinical characteristic     risk    

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Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 1-9 doi: 10.1007/s11684-015-0381-3

Abstract:

With the cure rate of childhood acute lymphoblastic leukemia (ALL) approaching 90%, further improvementpatients will require better understanding of the mechanisms of drug resistance, identifying new leukemic cellDeeper characterization of leukemic cell genetic abnormalities has discovered new subtypes of leukemiasuch as early T-cell precursor ALL and Philadelphia chromosome-like ALL, and identified many genomic

Keywords： pharmacogenomics     acute lymphoblastic leukemia     genomics     pharmacogenetics    

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Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 347-371 doi: 10.1007/s11684-020-0821-6

Abstract: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by genetic alterations withinhibitors (e.g., imatinib), immunomodulators, monoclonal antibodies, and chimeric antigen receptor T-cell

Keywords： BCP-ALL     subtypes     translocation     aneuploidy     sequence mutations    

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Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal ResidualDisease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation Article

Yifei Cheng,Yuhong Chen,Chenhua Yan,Yu Wang,Xiangyu Zhao,Yao Chen,Wei Han,Lanping Xu,Xiaohui Zhang,Kaiyan Liu,Shasha Wang,Lungji Chang,Lei Xiao,Xiaojun Huang

Engineering 2019, Volume 5, Issue 1,   Pages 150-155 doi: 10.1016/j.eng.2018.12.006

Abstract: cell transplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL).Donor lymphoblastic infusion (DLI) is the main established approach to treat B-ALL with MRD after allo-HSCTThree of the six patients are currently alive without leukemia.No patient developed acute graft-versus-host disease (aGVHD), and no patient died of cytokine releasein B-ALL after allo-HSCT and for those who were not responsive to DLI.

Keywords： Donor-derived CD19-targeted T cell infusion     Hematopoietic stem cell transplantation     B cell acute lymphoblasticleukemia     Minimal residual disease    

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imatinib plus CALLG2008 protocol in adult patients with newly diagnosed Philadelphia chromosome-positive acutelymphoblastic leukemia

Yinjun Lou, Yafang Ma, Chenyin Li, Sansan Suo, Hongyan Tong, Wenbin Qian, Wenyuan Mai, Haitao Meng, Wenjuan Yu, Liping Mao, Juyin Wei, Weilei Xu, Jie Jin

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 229-238 doi: 10.1007/s11684-017-0506-y

Abstract:

A CALLG2008 protocol was developed by the Chinese Acute Lymphoblastic Leukemia Cooperative Group foradult acute lymphoblastic leukemia (ALL).Fifty-eight (36 with haploidentical donor) patients underwent allogeneic hematopoietic stem cell transplantation

Keywords： Philadelphia chromosome     acute lymphoblastic leukemia     imatinib     CALLG2008    

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Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract:

Genetic mutations are considered to drive the development of acute myeloid leukemia (AML).mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing the full-blown leukemia

Keywords： preleukemic stem cell     acute myeloid leukemia     relapse     DNMT3A    

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Chimeric antigen receptor T cell therapies for acute myeloid leukemia

Bin Gu, Jianhong Chu, Depei Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 701-710 doi: 10.1007/s11684-020-0763-z

Abstract: Abstract Chimeric antigen receptor T cell (CAR T) therapies have achieved unprecedented efficacy in B-cellAcute myeloid leukemia (AML) is a group of heterogeneous myeloid malignancies.Allogeneic hematopoietic stem cell transplantation could be an effective therapy because of the graft-versus-leukemia

Keywords： acute myeloid leukemia     CAR T     immunotherapy    

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unmanipulated allogeneic transplantation could be used as a salvage option for patients with relapsed acuteleukemia post-chemotherapy plus modified donor lymphocyte infusion

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 728-739 doi: 10.1007/s11684-021-0833-x

Abstract: Relapse is the main problem after allogeneic hematopoietic stem cell transplantation (allo-HSCT).However, little is known about the efficacy of HSCT2 in patients with relapsed/refractory acute leukemia

Keywords： second hematopoietic stem cell transplantation     acute leukemia     relapse     chemotherapy     modified donor    

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Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 356-362 doi: 10.1007/s11684-010-0220-5

Abstract: Acute myeloid leukemia (AML) is a very heterogeneous neoplasm of the hematopoietic stem cell.

Keywords： acute myeloid leukemia     mutations     risk stratification    

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Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 323-328 doi: 10.1007/s11684-010-0026-5

Abstract: This study explored the effects of nuclear factor-kappa B (NF-κB) inhibitor Bay 11-7082 on Fas/FasL systemand Fas-mediated apoptosis in cell line HL-60 cells.

Keywords： nuclear factor-kappa B     Fas/FasL system     HL-60     Bay 11-7082    

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Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research

Jiong HU

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 45-52 doi: 10.1007/s11684-011-0117-y

Abstract:

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia.directly degrades the PML-RARα fusion transcript, leading to the differentiation and apoptosis of leukemiacells and the potential eradication of APL leukemia-initiating cells (LICs), thus making the diseasea potentially curable type of leukemia.

Keywords： acute promyelocytic leukemia     arsenic     all-trans retinoic acid     survival    

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Title Author Date Type Operation

characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cellacute lymphoblastic leukemia: targeted immunotherapy for acute lymphoblastic leukemia

Journal Article

Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen

Journal Article

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Journal Article

Precision medicine in acute lymphoblastic leukemia

Ching-Hon Pui

Journal Article

Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese

Journal Article

Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

Ching-Hon Pui

Journal Article

Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen

Journal Article

Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal ResidualDisease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation

Yifei Cheng,Yuhong Chen,Chenhua Yan,Yu Wang,Xiangyu Zhao,Yao Chen,Wei Han,Lanping Xu,Xiaohui Zhang,Kaiyan Liu,Shasha Wang,Lungji Chang,Lei Xiao,Xiaojun Huang

Journal Article

imatinib plus CALLG2008 protocol in adult patients with newly diagnosed Philadelphia chromosome-positive acutelymphoblastic leukemia

Yinjun Lou, Yafang Ma, Chenyin Li, Sansan Suo, Hongyan Tong, Wenbin Qian, Wenyuan Mai, Haitao Meng, Wenjuan Yu, Liping Mao, Juyin Wei, Weilei Xu, Jie Jin

Journal Article

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse

Yuting Tan,Han Liu,Saijuan Chen

Journal Article

Chimeric antigen receptor T cell therapies for acute myeloid leukemia

Bin Gu, Jianhong Chu, Depei Wu

Journal Article

unmanipulated allogeneic transplantation could be used as a salvage option for patients with relapsed acuteleukemia post-chemotherapy plus modified donor lymphocyte infusion

Journal Article

Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Journal Article

Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Journal Article

Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research

Jiong HU

Journal Article